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地板
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发表于 2015-10-7 12:30:37
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Two further studies in the 1990s gave mixed results. One unpublished study showed weak linkage to the Xq28 region, whereas a second in 1999 studying Canadian material consisting of 52 pairs of gay brothers found no statistically significant linkage in alleles and haplotypes and concluded against an X-linked male homosexuality gene.[12] Hamer's meta-analysis of all data available at that time (i.e., two of his own studies, the Canadian study, and the unpublished study) indicated Xq28 has a significant but not exclusive effect.[13]
In 2012, results from the first large, comprehensive multi-center genetic linkage study of male sexual orientation were reported by an independent group of researchers at the American Society of Human Genetics.[14] The study population included 409 independent pairs of gay brothers, who were analyzed with over 300,000 single-nucleotide polymorphism markers. The data strongly replicated Hamer?s Xq28 findings as determined by both two-point and multipoint (MERLIN) LOD score mapping. Significant linkage was also detected in the pericentromeric region of chromosome 8, overlapping with one of the regions detected in a previous genomewide linkage study by the Hamer lab.[15] The authors concluded that "our findings, taken in context with previous work, suggest that genetic variation in each of these regions contributes to development of the important psychological trait of male sexual orientation." The authors described their findings in greater detail in an article published in November 2014. |
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